The Tex-Mex Casserole: A Comforting Classic for Every Occasion

There’s something about the aroma of a Tex-Mex casserole that immediately evokes nostalgia. This dish, a hearty blend of spiced chicken, vegetables, and melted cheese, has long been a favorite at family gatherings, church suppers, and neighborhood potlucks. Its roots trace back to an era when casseroles ruled the dinner table—a time when comfort food meant something hearty, easy to share, and always crowd-pleasing. Though often linked to the famed King Ranch in Texas, this casserole is more likely the invention of a women’s Junior League, designed to bring warmth and flavor to gatherings.
Whether you’re hosting a casual dinner or preparing a dish to take to a friend’s house, the Tex-Mex casserole brings a little taste of the Southwest to every bite. The blend of chili powder, roasted peppers, and cumin makes this dish irresistible, balancing spicy heat with rich, creamy textures. Here’s how you can recreate this satisfying meal in your own kitchen.
Key Ingredients: What You’ll Need
A Tex-Mex casserole is a marriage of bold spices, smoky chicken, and the comforting combination of melted cheese and soft tortillas. Here’s a breakdown of the essential ingredients:
- Butter: The base for sautéing the onions and peppers, creating a rich and flavorful foundation.
- Yellow Onion, Red Bell Pepper, Poblano Peppers, and Jalapeño: A colorful mix of vegetables that bring both sweetness and heat to the dish. The poblano peppers add a smoky note, while the jalapeño brings just enough spice to make things exciting.
- Garlic, Chili Powder, and Cumin: The aromatic trifecta that infuses the casserole with a distinctly Tex-Mex flavor.
- Kosher Salt and Black Pepper: Simple seasonings to round out the dish’s taste.
- All-Purpose Flour: Used to thicken the sauce, giving the casserole a creamy consistency.
- Chicken Broth and Diced Tomatoes with Green Chiles: These ingredients add depth to the casserole’s sauce, enhancing the flavor profile with tang and richness.
- Sour Cream: A creamy touch that balances out the spices and gives the casserole its velvety texture.
- Smoked Chicken: The star of the dish, this tender, shredded chicken is both flavorful and easy to work with. Smoked chicken gives the casserole a rich, savory depth.
- Fresh Cilantro: Brightens up the dish and adds a fresh contrast to the richness.
- Monterey Jack and Sharp Cheddar Cheese: The perfect blend of cheeses for melting—Monterey Jack for smoothness, and Cheddar for a bit of sharp tang.
- Corn Tortillas: The base for the casserole layers, they hold everything together and add that comforting, familiar texture.
Step-by-Step Directions: How to Make a Tex-Mex Casserole
- Prepare the Vegetable Base:
Start by melting butter in a large skillet over medium-high heat. Add the onion, red bell pepper, poblano peppers, and jalapeño, cooking them for 8 to 10 minutes, or until they’ve softened and turned golden. Stir in the garlic, chili powder, cumin, salt, and black pepper, cooking for another minute until fragrant. - Make the Sauce:
Sprinkle flour over the softened vegetables, and cook for another minute, stirring constantly. Gradually whisk in the chicken broth and bring the mixture to a boil over high heat, stirring continuously. Allow it to boil for 1 to 2 minutes, or until the sauce has thickened. Once thickened, remove from heat and stir in the diced tomatoes with green chiles and sour cream. - Combine the Chicken and Cilantro:
In a separate bowl, mix the shredded smoked chicken with chopped cilantro. Add the vegetable mixture to the chicken, and stir everything together. This is your filling for the casserole, rich and flavorful. - Prepare the Tortillas:
Heat a large cast-iron skillet over high heat. Lightly brush each corn tortilla on both sides with canola oil, and cook them in batches for 1 to 2 minutes on each side, until they’re lightly browned and crispy. - Assemble the Casserole:
Lightly grease a 13×9-inch baking dish with cooking spray. Begin by lining the bottom with 6 tortillas, overlapping them slightly to cover the surface. Spread half of the chicken and vegetable mixture over the tortillas, and top with one-third of the combined Monterey Jack and Cheddar cheese. Repeat the layers once more, finishing with a final layer of tortillas and cheese on top. - Bake the Casserole:
Cover the dish with a sheet of aluminum foil that’s been lightly sprayed with cooking spray. Bake in a preheated oven at 375°F for 20 minutes. After 20 minutes, uncover the casserole and bake for another 10 minutes, or until the cheese is bubbly and the top is lightly browned. Allow the casserole to stand for 10 minutes before serving.
Why This Casserole is a Winner
This Tex-Mex casserole is the epitome of comfort food—rich, satisfying, and full of bold flavors. The smoky heat from the poblano peppers and jalapeño is perfectly balanced by the creaminess of the sour cream and the richness of the smoked chicken. Layered between soft tortillas and melted cheese, it’s the kind of dish that’s both familiar and exciting.
Whether it’s a family dinner, a potluck, or a holiday gathering, this casserole has the kind of flavor that makes everyone ask for seconds. And with its simplicity and hearty ingredients, it’s also a perfect dish to prep ahead of time, making it ideal for busy weeknights or last-minute events.